Open AccessLiver and COVID-19: possible mechanisms of damage
Author(s) -
Marina G. Mnatsakanyan,
А. П. Погромов,
А. С. Лишута,
Victоr Fоmin,
Ольга Сергіївна Волкова,
O. V. Tashchyan,
Irina V. Kuprina,
Yuliia F. Shumskaya
Publication year - 2021
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.26442/00403660.2021.04.200733
Subject(s) - pneumonia , covid-19 , medicine , alanine aminotransferase , coronavirus , gastroenterology , betacoronavirus , immunology , disease , infectious disease (medical specialty)
The global epidemic of a new coronavirus infection caused by SARS-CoV-2 is a major threat to human health. In the clinical picture, along with acute respiratory distress syndrome, liver lesions are also noted. The following mechanisms are currently being considered: direct damaging effects of SARS-CoV-2, immuno-mediated inflammation, hypoxia, drug exposure, and reactivation of pre-existing liver disease. We studied 150 patients with COVID-pneumonia who are under inpatient treatment at the University Clinical Hospital No. 1 of Sechenov First Moscow State Medical University. Of these, the presence of SARS-CoV-2 RNA was confirmed by polymerase chain reaction in 84 (56.0%) patients. In 55 (36.7%) patients, an increase in serum aminotransferases was registered, mainly alanine aminotransferase max. up to 572 U/L and aspartate aminotransferase up to a max. of 232 U/L. The long-term consequences are unknown and require monitoring of these patients.