Open AccessThe Wonderful DMARD with Multiple Toxicities
Author(s) -
Yashika Kaushal,
Ratibha Kausal,
Isha Sharma
Publication year - 2021
Publication title -
international healthcare research journal
Language(s) - English
Resource type - Journals
ISSN - 2456-8090
DOI - 10.26440/ihrj/0507.10470
Subject(s) - methotrexate , tolerability , discontinuation , medicine , adverse effect , drug , pharmacology , toxicity , intensive care medicine , chemotherapy , adverse drug reaction , disease
Methotrexate is a type of disease-modifying anti-rheumatic drug (DMARD). It is used to reduce activity of the immune system for people who have certain conditions. Methotrexate is a chemotherapy agent and immune system suppressant. Its use may be limited by concerns regarding its adverse reactions. The occurrence of adverse drug reactions in some cases leads to the therapy discontinuation. Although adverse drug reactions (ADR) of methotrexate generally do not pose a serious threat to the health of patients and a reduction in the dose of methotrexate leads to their elimination, in some cases severe toxicities of the drug occur unpredictably. These facts explain the need for close monitoring of the patient’s condition and the identification of potential risk factors for drug toxicity on the part of different organs and functional systems. The purpose of this review is to detail about safety and tolerability of methotrexate.