Medically Significant Hypersensitivity Reaction to Dapsone: A Case Report

The drug Dapsone is a component of the World Health Organization multidrug therapy being used against leprosy. Although it has shown a good efficacy during the years, a few subjects develop adverse drug reactions associated with dapsone .We report a case of a patient who was prescribed dapsone as part of multiple drug therapy for leprosy following which he developed Dapsone induced Hypersensitivity Syndrome (DHS). He was prescribed steroids with a tapering dose. His condition worsened after weaning of the oral steroids. He also developed steroid-induced diabetes which was stabilized using anti-diabetic drugs.