Open AccessGenome Wise Identification and Phylogenetic Analyses of NOTCH1 Gene
Author(s) -
Mazhar MW,
M Sikandar,
S Saif,
J Mahmood,
Husnain Aslam,
F Mazhar,
H Tahir,
A Raza,
Shehzad MB
Publication year - 2021
Publication title -
austin journal of pharmacology and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2373-6208
DOI - 10.26420/austinjpharmacolther.2021.1144
Subject(s) - biology , intron , notch signaling pathway , gene , exon , genetics , genome , transcription factor , computational biology
The NOTCH gene encode transmembrane receptor. It play a vital role in several process stem cell maintenance and differentiation during embryonic and adult development. When ligand bind at a specific part intracellular part of NOTCH receptor is cleaved and translocate to the nucleus from where it can bind to transcription site. NOTCH activity can promotes tissue growth and cancer in some conditions but they also suppress tumors formation in others. Their gene structure show the amount of introns and exons by a dimensions structure of NOTCH gene. (Powell, Passmore et al. 1998)Various tools or database such as Mega7, Pfam and Gene structure and display server are used to analyze their phylogeny and their chromosome positions gene structure and introns and exons. Further studies are made to target the NOTCH pathway on growth and cancer suppressor.