Open AccessEvaluation of a new rapid-diagnostic test for peritonitis in peritoneal dialysis: the PERIPLEX® device.
Author(s) -
Pierre–Yves Durand,
Christian Verger
Publication year - 2020
Publication title -
bulletin de la dialyse à domicile
Language(s) - English
Resource type - Journals
ISSN - 2607-9917
DOI - 10.25796/bdd.v3i4.57953
Subject(s) - peritoneal dialysis , peritonitis , medicine , false positive paradox , predictive value , sepsis , positive predicative value , prospective cohort study , gastroenterology , surgery , machine learning , computer science
In 2017, the British company MOLOGIC developed a new rapid-diagnostic test (PERIPLEX®) for the diagnosis of peritonitis in patients undergoing peritoneal dialysis. This single-use test is based on the detection in dialysate of two biomarkers of bacterial infection: Interleukin-6 (IL-6) and matrix metalloproteinase-8 (MMP-8). The test was evaluated in a prospective multicenter study including 10 centers from the RDPLF (French Language Peritoneal Dialysis Registry). A total of 184 tests were performed; 86 tests were negative and 98 were positive. 85 peritonitis were confirmed. There were no false-negatives, and 13 false-positives. Of the 13 false-positives, 7 of them were for sepsis without peritonitis, or peritoneal inflammation. The performance of the test is considered excellent: sensitivity 100%, specificity 86.9%, positive predictive value 86.7%, negative predictive value 100%. In this study, a negative test can formally rule out the diagnosis of peritonitis.