Open AccessMedicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future
Author(s) -
Jonathan Hall,
Anastasia Lepikhina,
Jan Philipp Becker,
Artur Łaski,
Eva-Maria Manz,
Štefan Moravčík,
Sebastian Sjöström,
Mathilde Vincent
Publication year - 2022
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2022.466
Subject(s) - oligonucleotide , chemistry , nanotechnology , engineering ethics , engineering , materials science , biochemistry , dna
The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years. Much of the progress in this field is due to advances in the medicinal chemistry of oligonucleotides,combined with a judicious choice of molecular targets and disease areas. In this perspective, we describe the growth of this new class of drugs highlighting selected milestones in oligonucleotide medicinal chemistry.