Open AccessRadical Alkynylations with EthynylBenziodoXolones: from Photocatalysis to Direct Excitation
Author(s) -
Stephanie G. E. Amos,
Jérôme Waser
Publication year - 2022
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2022.312
Subject(s) - photocatalysis , radical , reagent , alkynylation , chemistry , photochemistry , excitation , nanotechnology , catalysis , combinatorial chemistry , materials science , organic chemistry , engineering , electrical engineering
Ethynylbenziodoxolones (EBXs) have recently emerged as potent reagents for the alkynylation of radicals. Their combination with photocatalysis allows the synthesis of valuable alkynes at room temperature. Herein, we discuss two photomediated strategies for the synthesis of internal alkynes. The first transformation is a 1,2-oxyalkynylation of N- and O-alkenes using 4ClCzIPN as a photocatalyst. The second strategy makes use of EBXs as strong photooxidants allowing the oxidation of a variety of substrates with no need for a photocatalyst.