Open AccessHeterogeneous Metal-Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
Author(s) -
Daniele Cartagenova,
Stephan Bachmann,
Jeroen A. van Bokhoven,
Kurt Püntener,
Marco Ranocchiari
Publication year - 2021
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2021.972
Subject(s) - catalysis , homogeneous , coupling reaction , heterogeneous catalysis , chemistry , combinatorial chemistry , coupling (piping) , organic chemistry , materials science , mathematics , metallurgy , combinatorics
The synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. Suzuki Miyaura cross coupling is a fundamental C-C bond-forming reaction to produce complex DS intermediates. The present contribution points out the way, in which the synthesis of DS intermediates by C-C cross coupling can be economically competitive, while minimizing waste by selecting the appropriate heterogeneous catalyst. By comparing homogeneous, immobilized heterogeneous catalysts on silica and metal-organic framework (MOF) catalysts, while considering the perspectives of academia and industry, the critical parameters for a successful industrial application of heterogeneous catalytic Suzuki Miyaura cross coupling reactions were identified. Heterogeneous catalysts, such as MOFs, may provide the complementary platform for reducing waste and the costs of production related to such transformations.