Open AccessFrom Academia to the Market – Air-stable Ni(II)/Josiphos Catalysts
Author(s) -
Florian Bächle,
Achim Link,
Abderrahmane Amgoune,
Anis Tlili
Publication year - 2021
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2021.943
Subject(s) - catalysis , aryl , commercialization , ammonia , chemistry , acetone , nickel , polymer chemistry , organic chemistry , combinatorial chemistry , business , alkyl , marketing
The design, synthesis, commercialization and application of air stable Ni(II)/Josiphos complexes has been realized in a collaboration between Solvias and ICBMS (University Lyon 1). The Ni-complexes are utilized as versatile precatalysts for diverse cross coupling reactions. Apart from being active in established C–C and C–N couplings at low catalyst loadings, the novel Ni-precatalysts enabled the development of the challenging monoarylation of ammonia, ammonia surrogates and even alkylammonium chlorides with aryl carbamates. Finally, the alpha-arylation of acetone with aryl chlorides, carbamates and pivalates was demonstrated using the Ni(II)/Josiphos precatalysts.