Open AccessChemical Biology Tools to Study Lipids and their Metabolism with Increased Spatial and Temporal Resolution
Author(s) -
Clémence Simon,
Suihan Feng,
Howard Riezman
Publication year - 2021
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2021.1012
Subject(s) - lipid metabolism , computational biology , biology , metabolism , cellular metabolism , evolutionary biology , biochemistry
Lipids are important cellular components providing many essential functions. To fulfill these various functions evolution has selected for a diverse set of lipids and this diversity is seen at the organismal, cellular and subcellular level. Understanding how cells maintain this complex lipid organization is a very challenging problem, which for lipids, is not easily addressed using biochemical and genetic techniques. Therefore, chemical tools have an important role to play in our quest to understand the complexities of lipid metabolism. Here we discuss new chemical tools to study lipids, their distribution and metabolism with increased spatial and temporal resolution.