Open AccessFouling of Flow Reactors in Organolithium Mediated Transformations: Experience on Scale-up and Proposed Solution
Author(s) -
P Filipponi,
Bertrand Guélat,
Julien Haber,
Serena Mostarda,
R. ÓMeadhra,
Lorenzo Piccioni,
Jutta Polenk,
Berthold Schenkel,
Silke Schoenebeck,
Alexander Streit,
Roger Suremann,
Francesco Venturoni,
Stefan Wegmann
Publication year - 2019
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2019.809
Subject(s) - fouling , process engineering , robustness (evolution) , computer science , reliability (semiconductor) , scale (ratio) , biochemical engineering , scale up , flow (mathematics) , environmental science , continuous flow , batch reactor , process (computing) , chemistry , engineering , mechanics , physics , thermodynamics , biochemistry , power (physics) , classical mechanics , quantum mechanics , membrane , gene , operating system , catalysis
Continuous processing has been demonstrated to be a superior approach when applied to fast and energetic chemical transformations. Indeed, whereas classical batch or semi-batch methods require cryogenic conditions and slow addition rates of reactive species, flow technologies enable rapid mixing of synthetic partners in a highly controlled environment. As a result, low yielding and dangerous processes in batch can be performed at scale in a cost competitive and safer continuous manner. Despite the advantages of higher quality and safety, the perennial problems of solids build-up and pipe fouling threaten the robustness and reliability of flow processes. In this contribution, a new methodology to prevent reactor fouling is reported and discussed. The implementation of this methodology has been decisive in solving fouling issues encountered during the piloting of an organolithium based flow process.