Open AccessMagneto-responsive Cell Culture Substrates that can be Modulated in situ
Author(s) -
Federica Crippa,
Barbara RothenRutishauser,
Alke PetriFink
Publication year - 2019
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2019.51
Subject(s) - mechanobiology , in situ , materials science , nanotechnology , superparamagnetism , nanoparticle , substrate (aquarium) , iron oxide nanoparticles , stimulus (psychology) , biophysics , chemistry , magnetic field , physics , microbiology and biotechnology , biology , magnetization , ecology , psychology , organic chemistry , quantum mechanics , psychotherapist
Understanding the interaction between cells and their environment is fundamental for mechanobiology. To mimic the behavior of cells in physiological and pathological conditions, synthetic substrates must have topographical and/or mechanical properties that evolve in time. Dynamic substrates mainly rely on stimuli-responsive materials where an external stimulus induces controlled variations in topography or mechanics. Herein, we describe the development of a dynamic cell culture substrate where mechanical properties are reversibly tuned in situ using magnetically-responsive superparamagnetic iron oxide nanoparticles (SPIONs).