Open AccessSynergistic Action of Copper Catalysts and Lewis Acids in Carbon–Carbon Bond Forming Reactions
Author(s) -
M. K. Das,
Syuzanna R. Harutyunyan
Publication year - 2018
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2018.642
Subject(s) - chemistry , electrophile , catalysis , reactivity (psychology) , reagent , lewis acids and bases , combinatorial chemistry , copper , carbon fibers , selectivity , organic chemistry , molecule , reactive intermediate , materials science , medicine , alternative medicine , pathology , composite number , composite material
Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric C–C bond forming reactions. In this review we will discuss various examples where the application of this strategy provides access to efficient catalytic processes for the synthesis of chiral molecules such as alcohols, amides and heteroarenes.