Open AccessDiscovery of Eco-compatible Synthetic Paths by a Multi-catalysis Approach
Author(s) -
Jean Rodríguez,
Adrien Quintard
Publication year - 2018
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2018.580
Subject(s) - enantioselective synthesis , catalysis , allylic rearrangement , combinatorial chemistry , biochemical engineering , simple (philosophy) , computer science , nanotechnology , chemistry , organic chemistry , materials science , engineering , philosophy , epistemology
This article summarizes our recent developments in the discovery of multi-catalytic reactions. By efficiently taking the best from different worlds, the combination of several catalytic principles allows the invention of eco-compatible transformations rapidly assembling simple building blocks into elaborated enantioenriched molecules. This type of approach was successfully illustrated in the synthesis of cyclohexenones, keto-diols or in the direct functionalization of allylic alcohols by an enantioselective borrowing hydrogen. In addition, mechanistic understanding of the role of the different constituents enabled the fine-tuning of the catalytic systems considerably improving the efficiency notably in terms of enantiocontrol.