Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer | Zendy

Sarah Saint-Auret | Zendy; AnneCaroline Chany | Zendy; Virginie Casarotto | Zendy; Cédric Tresse | Zendy; Lise Parmentier | Zendy; Hajer Abdelkafi | Zendy; Nicolas Blanchard | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer

Author(s) -

Sarah Saint-Auret,

AnneCaroline Chany,

Virginie Casarotto,

Cédric Tresse,

Lise Parmentier,

Hajer Abdelkafi,

Nicolas Blanchard

Publication year - 2017

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2017.836

Subject(s) - buruli ulcer , mycobacterium ulcerans , exotoxin , microbial toxins , biology , microbiology and biotechnology , computational biology , toxin , disease , medicine , pathology

Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research