Open AccessTotal Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer
Author(s) -
Sarah Saint-Auret,
AnneCaroline Chany,
Virginie Casarotto,
Cédric Tresse,
Lise Parmentier,
Hajer Abdelkafi,
Nicolas Blanchard
Publication year - 2017
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2017.836
Subject(s) - buruli ulcer , mycobacterium ulcerans , exotoxin , microbial toxins , biology , microbiology and biotechnology , computational biology , toxin , disease , medicine , pathology
Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.