Open AccessEngineering Nanosized Organosilica for Molecular Recognition and Biocatalysis Applications
Author(s) -
M. Rita Correro,
Yves Dudal,
Philippe Corvini,
Patrick Shahgaldian
Publication year - 2017
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2017.243
Subject(s) - biocatalysis , template , molecular recognition , nanomaterials , nanotechnology , materials science , nanometre , sorting , synthetic biology , computer science , chemistry , catalysis , molecule , computational biology , organic chemistry , biology , ionic liquid , composite material , programming language
A series of synthetic nanomaterials capable of molecular recognition and/or biocatalysis have been produced by exploiting the self-sorting, self-assembly and polycondensation of organosilane building blocks around protein templates. The established methodology allows for the production of thin organosilica layers of controlled thickness, down to nanometer precision. Fully synthetic virus recognition materials have been shown to specifically bind their target virus down to picomolar concentrations. The shielding of natural enzymes allowed producing nanobiocatalysts functioning under harsh operational conditions.