Open AccessDaring the Challenge and Thinking Big: The Value of Early Process R&D
Author(s) -
Stefan Abele,
JacquesAlexis Funel,
G. Schmidt,
Christian Moessner,
Mischa Schwaninger,
Roger Martí
Publication year - 2016
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2016.502
Subject(s) - enantioselective synthesis , yield (engineering) , diastereomer , intramolecular force , chemistry , enantiomer , reagent , diene , organocatalysis , diels–alder reaction , combinatorial chemistry , atom economy , aldol reaction , catalysis , organic chemistry , materials science , natural rubber , metallurgy
The production of the L/T channel blocker ACT-280778 required the enantiomerically pure 5-phenylbicyclo[2.2.2]oct-5-en-2-one (1) as key building block. As the published routes towards 1 are very low yielding (