Daring the Challenge and Thinking Big: The Value of Early Process R&D | Zendy

Stefan Abele | Zendy; JacquesAlexis Funel | Zendy; G. Schmidt | Zendy; Christian Moessner | Zendy; Mischa Schwaninger | Zendy; Roger Martí | Zendy

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Daring the Challenge and Thinking Big: The Value of Early Process R&D

Author(s) -

Stefan Abele,

JacquesAlexis Funel,

G. Schmidt,

Christian Moessner,

Mischa Schwaninger,

Roger Martí

Publication year - 2016

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2016.502

Subject(s) - enantioselective synthesis , yield (engineering) , diastereomer , intramolecular force , chemistry , enantiomer , reagent , diene , organocatalysis , diels–alder reaction , combinatorial chemistry , atom economy , aldol reaction , catalysis , organic chemistry , materials science , natural rubber , metallurgy

The production of the L/T channel blocker ACT-280778 required the enantiomerically pure 5-phenylbicyclo[2.2.2]oct-5-en-2-one (1) as key building block. As the published routes towards 1 are very low yielding (

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