Transition Metal-free Methylation of Amines with Formaldehyde as the Reductant and Methyl Source | Zendy

Nikki Y. T. Man | Zendy; Wanfang Li | Zendy; Scott G. Stewart | Zendy; XiaoFeng Wu | Zendy

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Transition Metal-free Methylation of Amines with Formaldehyde as the Reductant and Methyl Source

Author(s) -

Nikki Y. T. Man,

Wanfang Li,

Scott G. Stewart,

XiaoFeng Wu

Publication year - 2015

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2015.345

Subject(s) - formaldehyde , steric effects , chemistry , methylation , transition metal , primary (astronomy) , metal , organic chemistry , catalysis , biochemistry , physics , astronomy , gene

A simple transition metal-free procedure using formal dehyde for the N,N-dimethylation and N-methylation of primary and secondary anilines is reported. The reaction showed limitations on sterically hindered and electron-withdrawing anilines, but is successful on amines with electron-donating substituents. Formaldehyde acts as both the reducing agent and the carbon source in the reaction.

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