Open AccessAcid Mediated Ring Closing Metathesis: A Powerful Synthetic Tool Enabling the Synthesis of Clinical Stage Kinase Inhibitors
Author(s) -
Anthony D. William,
Angeline C.-H. Lee
Publication year - 2015
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2015.142
Subject(s) - olefin metathesis , ring closing metathesis , metathesis , combinatorial chemistry , chemistry , salt metathesis reaction , stereochemistry , organic chemistry , polymerization , polymer
The powerful olefin metathesis reaction was employed for the construction of late-phase clinical agents SB1317 and SB1518. In both cases RCM seems to proceed only in the presence of an acid and to predominantly furnish trans isomers. In case of SB1518 it proceeded in the presence of acid HCl, while for SB1317, it mainly proceeds in the presence of TFA (trifluroacetic acid).