Open AccessAdventures in Drug-like Chemistry Space: From Oxetanes to Spiroazetidines and Beyond!
Author(s) -
Mark RogersEvans,
Henner Knust,
JeanMarc Plancher,
Erick M. Carreira,
George Wuitschik,
Johannes A. Burkhard,
Dong B. Li,
Carine Guérot
Publication year - 2014
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2014.492
Subject(s) - chemical space , drug discovery , component (thermodynamics) , process (computing) , nanotechnology , computer science , computational biology , palette (painting) , chemistry , biology , materials science , bioinformatics , physics , programming language , operating system , thermodynamics
Recently we have documented research efforts aimed at new classes of oxetanes as well as spiroheteroalicyclic ring systems (which we have termed 'Compact Modules') designed to expand the palette of tailored module scaffolds available to medicinal chemists, which constitute an important role for synthetic chemistry in the drug discovery process. An essential component for this process is to provide access to specific molecular topologies with functional group diversity, essential for generating leads that discriminate among biological targets, therefore promoting selectivity and enhancing the safety profile of the final clinical candidates.