An Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide | Zendy

Chantal Belie | Zendy; Andrew Plant | Zendy; Nick Mulholland | Zendy; Matthew M. W. McLachlan | Zendy; Derek McCormack | Zendy; Adrian Longstaff | Zendy; Tony Kozakiewicz | Zendy; Andy Knee | Zendy; Katharine Ingram | Zendy; Myriem El Qacémi | Zendy; Martin Diggelmann | Zendy; Jonathan W. P. Dallimore | Zendy; Anne J. Dalençon | Zendy; Eric D. Clarke | Zendy; Jutta Boehmer | Zendy; John Williams | Zendy

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An Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide

Author(s) -

Chantal Belie,

Andrew Plant,

Nick Mulholland,

Matthew M. W. McLachlan,

Derek McCormack,

Adrian Longstaff,

Tony Kozakiewicz,

Andy Knee,

Katharine Ingram,

Myriem El Qacémi,

Martin Diggelmann,

Jonathan W. P. Dallimore,

Anne J. Dalençon,

Eric D. Clarke,

Jutta Boehmer,

John Williams

Publication year - 2014

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2014.442

Subject(s) - moiety , electrophile , silylation , trifluoromethyl , fluoride , chemistry , combinatorial chemistry , sulfur , organic chemistry , catalysis , inorganic chemistry , alkyl

An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equivalent, which was reacted with a sulfur electrophile leading ultimately to the key difluorosulfide moiety.

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