Open AccessAn Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide
Author(s) -
Chantal Belie,
Jutta Boehmer,
Eric D. Clarke,
Anne J. Dalençon,
Jonathan W. P. Dallimore,
Martin Diggelmann,
Myriem El Qacemi,
Katharine Ingram,
Andy Knee,
Tony Kozakiewicz,
Adrian Longstaff,
Derek P. McCormack,
Matthew M. W. McLachlan,
Nick Mulholland,
Andrew Plant,
John Williams
Publication year - 2014
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2014.442
Subject(s) - moiety , electrophile , silylation , trifluoromethyl , fluoride , chemistry , combinatorial chemistry , sulfur , organic chemistry , catalysis , inorganic chemistry , alkyl
An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equivalent, which was reacted with a sulfur electrophile leading ultimately to the key difluorosulfide moiety.