Open AccessFrom Azidoproline to Functionalizable Collagen
Author(s) -
Christiane Siebler,
Roman S. Erdmann,
Helma Wennemers
Publication year - 2013
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2013.891
Subject(s) - supramolecular chemistry , acylation , click chemistry , chemistry , combinatorial chemistry , biochemistry , organic chemistry , molecule , catalysis
The article summarizes our research devoted to the development of functionalizable collagen using azidoproline-containing model peptides. 'Click chemistry' or Staudinger reduction followed by acylation provided facile access to a range of differently functionalized collagen model peptides bearing e.g. carbohydrates. The research provided not only insight into the factors that are responsible for the high conformational stability of collagen but also a guide in which positions functional moieties are tolerated without or by deliberately disturbing the supramolecular assembly of collagen. The presented research will be useful for the development of collagen-based materials.