Open AccessBachem – Insights into Peptide Chemistry Achievements by the World's Leading Independent Manufacturer of Peptides
Author(s) -
M. Mergler,
Günther Loidl,
Martina Diekmann,
Fritz Dick
Publication year - 2013
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2013.874
Subject(s) - peptide , chemistry , peptide synthesis , combinatorial chemistry , nanotechnology , scale (ratio) , amino acid , fine chemical , biochemical engineering , organic chemistry , engineering , biochemistry , catalysis , materials science , physics , quantum mechanics
The Swiss fine chemicals company Bachem, pioneer and specialist in the chemical synthesis of peptides, has also become an internationally leading manufacturer of peptide active pharmaceutical ingredients (APIs). In response to increasing demands in scale and purity, Bachem's research efforts centered on the chemistry involved in solid-phase peptide synthesis and the production of the required amino acid derivatives with the aim of a continuous improvement of the technology. The resulting optimized protocols together with high-throughput equipment enabled us to manufacture long peptide APIs and, more recently, even pharma-grade glycoproteins in industrial scale.