Peptide-catalyzed 1,4-Addition Reactions of Aldehydes to Nitroolefins | Zendy

Robert Kastl | Zendy; Yukihiro Arakawa | Zendy; Jörg Duschmalé | Zendy; Markus Wiesner | Zendy; Helma Wennemers | Zendy

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Peptide-catalyzed 1,4-Addition Reactions of Aldehydes to Nitroolefins

Author(s) -

Robert Kastl,

Yukihiro Arakawa,

Jörg Duschmalé,

Markus Wiesner,

Helma Wennemers

Publication year - 2013

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2013.279

Subject(s) - conjugate , catalysis , addition reaction , stereoselectivity , chemistry , peptide , combinatorial chemistry , amino acid , organic chemistry , biochemistry , mathematics , mathematical analysis

Conjugate addition reactions of aldehydes to nitroolefins provide synthetically useful ?-nitroaldehydes. Here we summarize our research on peptide-catalyzed conjugate addition reactions of aldehydes to differently substituted nitroolefins. We show that peptides of the general type Pro-Pro-Xaa (Xaa = acidic amino acid) are not only highly active, robust and stereoselective catalysts but have also remarkable chemoselectivities.

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