Open AccessTeaching Enantioselectivity to C–H Bond Functionalizations: Initial Steps of a Rather Long Shot
Author(s) -
Nicolai Cramer
Publication year - 2012
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2012.869
Subject(s) - enantioselective synthesis , rhodium , surface modification , catalysis , palladium , chemistry , metal , combinatorial chemistry , one shot , organic chemistry , stereochemistry , engineering , mechanical engineering
The direct functionalization of non-activated C–H bonds, especially in an enantioselective manner, requires metal catalysts equipped with ligands with specifically designed properties. Examples for asymmetric C(sp2)–H and C(sp3)–H functionalizations using palladium- and rhodium catalysts are shown. This work was rewarded by the 2012 Werner Prize of the Swiss Chemical Society.