Reductive Cleavage of 2,2,2-Trichloroethyl Esters by Titanocene Catalysis | Zendy

Andreas Gansäuer | Zendy; Tobias Dahmen | Zendy

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Reductive Cleavage of 2,2,2-Trichloroethyl Esters by Titanocene Catalysis

Author(s) -

Andreas Gansäuer,

Tobias Dahmen

Publication year - 2012

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2012.433

Subject(s) - cleave , chemistry , catalysis , cleavage (geology) , aqueous solution , stoichiometry , reducing agent , organic chemistry , combinatorial chemistry , enzyme , materials science , composite material , fracture (geology)

Esters are of widespread use for protecting carboxylic acids in organic synthesis. However, methods to cleave esters often employ harsh conditions. Herein, we report a new and mild method for the reductive cleavage of 2,2,2-trichloroethylesters (TCE esters). Our radical method employs Cp2TiCl as an electron transfer catalyst and Zn dust as stoichiometric reducing agent. It avoids the use of strong Brønstedt-acids as well as aqueous conditions and can be carried out at room temperature.

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