Open AccessThe Life Sciences Mass Spectrometry Research Unit
Author(s) -
Gérard Hopfgartner,
Emmanuel Varesio
Publication year - 2012
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2012.335
Subject(s) - mass spectrometry , chemistry , mass spectrometry imaging , capillary electrophoresis–mass spectrometry , chromatography , protein mass spectrometry , sample preparation in mass spectrometry , analytical chemistry (journal) , tandem mass spectrometry , electrospray ionization
The Life Sciences Mass Spectrometry (LSMS) research unit focuses on the development of novel analytical workflows based on innovative mass spectrometric and software tools for the analysis of low molecular weight compounds, peptides and proteins in complex biological matrices. The present article summarizes some of the recent work of the unit: i) the application of matrix-assisted laser desorption/ionization (MALDI) for mass spectrometry imaging (MSI) of drug of abuse in hair, ii) the use of high resolution mass spectrometry for simultaneous qualitative/quantitative analysis in drug metabolism and metabolomics, and iii) the absolute quantitation of proteins by mass spectrometry using the selected reaction monitoring mode.