Open AccessNickamine: A General Catalyst for Cross Coupling of Alkyl Halides and Direct Alkylation
Author(s) -
Xile Hu
Publication year - 2012
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2012.154
Subject(s) - halide , alkylation , alkyl , pincer movement , catalysis , chemistry , nickel , coupling (piping) , medicinal chemistry , organic chemistry , materials science , metallurgy
A nickel pincer complex, Nickamine, is shown to be an active catalyst for a large number of reactions including cross coupling of non-activated alkyl halides and direct C–H alkylation of alkynes and aromatic heterocycles. This work was rewarded by the 2011 Werner Prize from the Swiss Chemical Society.