Active Methylene-based Multicomponent Reactions under Microwave Heating | Zendy

Bo Jiang | Zendy; ShuJiang Tu | Zendy

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Active Methylene-based Multicomponent Reactions under Microwave Heating

Author(s) -

Bo Jiang,

ShuJiang Tu

Publication year - 2011

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2011.925

Subject(s) - methylene , chemistry , combinatorial chemistry , yield (engineering) , chemical reaction , chemical synthesis , molecule , microwave heating , selectivity , microwave , reaction conditions , organic chemistry , nanotechnology , materials science , computer science , catalysis , telecommunications , biochemistry , metallurgy , in vitro

The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. MW-assisted active methylene-based multicomponent reactions serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity via a one-pot operation. This minireview covers our recent advances on multicomponent reactions involving active methylene compounds for the construction of bioactive molecule skeletons. In many cases, MW-assisted MCRs offer considerable improvements in selectivity, chemical yield and purity and constitutes a very simple and extremely rapid method to access a diverse range of heterocyclic motifs.

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