Open AccessSearching for the Protein Targets of Bioactive Molecules
Author(s) -
Christopher Chidley,
Hirohito Haruki,
Miriam Grønlund Pedersen,
Cindy Fellay,
Simone Moser,
Kai Johnsson
Publication year - 2011
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2011.720
Subject(s) - identification (biology) , computational biology , small molecule , sulfasalazine , drug discovery , drug , chemistry , biology , bioinformatics , biochemistry , medicine , pharmacology , botany , disease , pathology , ulcerative colitis
The identification of all protein targets of a given drug or bioactive molecule within the human body is a prerequisite for an understanding of its beneficial and deleterious activities. Current approaches to reveal protein targets often fail to reveal physiologically relevant interactions. Here we review a recently introduced yeast-based approach for the identification of the binding partners of small molecules. We discuss the advantages and limitations of the approach using the clinically approved drug sulfasalazine as an example.