Open AccessBicyclic Peptide Antagonists Derived from Genetically Encoded Combinatorial Libraries
Author(s) -
Christian Heinis
Publication year - 2011
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2011.677
Subject(s) - bicyclic molecule , peptide , combinatorial chemistry , chemistry , phage display , peptide library , chemical biology , computational biology , stereochemistry , biology , biochemistry , peptide sequence , gene
Ligands based on bicyclic peptides can combine favourable properties of antibodies (good binding affinity and target specificity) and small molecule ligands (stability, access to chemical synthesis, diffusion properties) and might be suitable molecular structures for the development of therapeutics. By using a combinatorial methodology based on phage display and a chemical cyclisation reaction, we are generating bicyclic peptide antagonists of protein targets with therapeutic applications in mind.