Bicyclic Peptide Antagonists Derived from Genetically Encoded Combinatorial Libraries | Zendy

Christian Heinis | Zendy

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Bicyclic Peptide Antagonists Derived from Genetically Encoded Combinatorial Libraries

Author(s) -

Christian Heinis

Publication year - 2011

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2011.677

Subject(s) - bicyclic molecule , peptide , combinatorial chemistry , chemistry , phage display , peptide library , chemical biology , computational biology , stereochemistry , biology , biochemistry , peptide sequence , gene

Ligands based on bicyclic peptides can combine favourable properties of antibodies (good binding affinity and target specificity) and small molecule ligands (stability, access to chemical synthesis, diffusion properties) and might be suitable molecular structures for the development of therapeutics. By using a combinatorial methodology based on phage display and a chemical cyclisation reaction, we are generating bicyclic peptide antagonists of protein targets with therapeutic applications in mind.

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