Open AccessHigh-Resolution and Tandem Mass Spectrometry – the Indispensable Tools of the XXI Century
Author(s) -
Yury O. Tsybin,
Luca Fornelli,
Anton N. Kozhinov,
Aleksey Vorobyev,
Saša M. Miladinović
Publication year - 2011
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2011.641
Subject(s) - mass spectrometry , fragmentation (computing) , tandem mass spectrometry , high resolution , chemistry , resolution (logic) , nanotechnology , analytical chemistry (journal) , computer science , chromatography , materials science , geology , remote sensing , artificial intelligence , operating system
Mass spectrometry-based qualitative and quantitative (bio)molecular analysis is a corner stone in the state-of-the-art pipelines in systems biology and environmental sciences. High-resolution and efficient tandem mass spectrometry methods and techniques are the essential analytical capabilities for the in-depth analysis of extremely complex mixtures of (bio)molecules of a very broad dynamic range of concentrations. Here, we briefly review the advantages and limitations of the current mass spectrometry with a focus on resolution, or resolving power, and methods of (bio)molecular fragmentation in the gas phase. We conclude with an outlook that considers possible avenues for further mass spectrometry-based method and technique development, indispensable for advancing the challenging real-life mass spectrometry applications in the XXI century.