Open AccessOn-line Reaction Monitoring of Lithiation of Halogen Substituted Acetanilides via in situ Calorimetry, ATR Spectroscopy, and Endoscopy
Author(s) -
Tamas A. Godany,
Yorck-Michael Neuhold,
Konrad Hungerbühler
Publication year - 2011
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2011.253
Subject(s) - acetanilide , calorimetry , spectroscopy , in situ , reaction calorimeter , halogen , infrared spectroscopy , chemistry , line (geometry) , ultraviolet visible spectroscopy , photochemistry , materials science , organic chemistry , physics , mathematics , alkyl , geometry , quantum mechanics , thermodynamics
Lithiation of N-(4-chlorophenyl)-pivalamide (NCP) and two additional substituted acetanilides: 4-fluoroacetanilide (4-F) and 4-chloroacetanilide (4-Cl) has been monitored by means of calorimetry, on-line ATR-IR and UV/vis spectroscopy and endoscopy. The combined on-line monitoring revealed the differences between the reaction paths of the chosen substrates. Thus the product structure and the reaction times for the individual reaction steps can be determined in situ.