Thermal Cleavage of the Fmoc Protection Group | Zendy

Stefan Höck | Zendy; Roger Martí | Zendy; Rainer Riedl | Zendy; Marina Simeunovic | Zendy

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Thermal Cleavage of the Fmoc Protection Group

Author(s) -

Stefan Höck,

Roger Martí,

Rainer Riedl,

Marina Simeunovic

Publication year - 2010

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2010.200

Subject(s) - protecting group , testability , group (periodic table) , chemistry , selectivity , base (topology) , combinatorial chemistry , cleavage (geology) , materials science , organic chemistry , mathematics , reliability engineering , engineering , mathematical analysis , alkyl , fracture (geology) , composite material , catalysis

The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.

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