Open AccessThermal Cleavage of the Fmoc Protection Group
Author(s) -
Stefan Höck,
Roger Martí,
Rainer Riedl,
Marina Simeunovic
Publication year - 2010
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2010.200
Subject(s) - protecting group , testability , group (periodic table) , chemistry , selectivity , base (topology) , combinatorial chemistry , cleavage (geology) , materials science , organic chemistry , mathematics , reliability engineering , engineering , mathematical analysis , alkyl , fracture (geology) , composite material , catalysis
The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.