Olefin Cyclopropanations via Sequential Atom Transfer Radical Addition-Dechlorination Reactions | Zendy

Katrin Thommes | Zendy; Kay Severin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Olefin Cyclopropanations via Sequential Atom Transfer Radical Addition-Dechlorination Reactions

Author(s) -

Katrin Thommes,

Kay Severin

Publication year - 2010

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2010.188

Subject(s) - olefin fiber , chemistry , atom (system on chip) , transfer (computing) , organic chemistry , computer science , catalysis , parallel computing , embedded system

In organic synthesis, cyclopropanation reactions are often performed with Simmons–Smith-type reagents or by transition metal catalyzed reactions of olefins with diazo compounds. A novel method for the synthesis of substituted cyclopropanes is described that is based on a two-step reaction sequence. Olefins are reacted with 1,1'-dichlorides in a Ru-catalyzed atom transfer radical addition (ATRA) process and the resulting 1,3-dichlorides are directly converted into cyclopropanes by reductive coupling with magnesium. This one-pot procedure is applicable to a variety of substrates and can be performed in an inter- or intramolecular fashion.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research