Open AccessLight-Activatable Nucleic Acids 'Caged' at the Nucleobases
Author(s) -
Maximilian C. R. Buff,
Timo Mack,
Alexander Heckel
Publication year - 2009
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2009.261
Subject(s) - nucleobase , nucleic acid , oligonucleotide , chemistry , combinatorial chemistry , biomolecule , molecule , nanotechnology , dna , biochemistry , organic chemistry , materials science
The attachment of photolabile groups to biologically active molecules offers a very versatile way to put a biological effect under the control of an external trigger signal and thus confers spatiotemporal and dose control to this effect. Over the last years we have prepared a number of oligonucleotide derivatives that are modified in such a way. These derivatives are usually referred to as 'caged compounds' and in particular our photolabile 'caging groups' are located at the nucleobases of oligonucleotides so that the Watson–Crick interaction is temporarily impossible. Thus several nucleic acid-based applications have now become controllable with light.