Open AccessRecent Progress in Iridium-Catalyzed Enantioselective Hydrogenation: Tetrasubstituted Olefins and Polyenes
Author(s) -
Marcus G. Schrems,
Aie Wang,
Andreas Pfaltz
Publication year - 2008
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2008.506
Subject(s) - enantioselective synthesis , iridium , stereocenter , noyori asymmetric hydrogenation , catalysis , asymmetric hydrogenation , chemistry , organic chemistry , catalytic hydrogenation , combinatorial chemistry
Iridium-catalyzed enantioselective hydrogenation has become the method of choice to convert prochiral unfunctionalized olefins to optically active compounds. Recently, we reported on applications giving access to more than one stereocenter in a single hydrogenation step. In this account we present recent developments in the hydrogenation of tetrasubstituted unfunctionalized olefins and isoprenoid polyenes, which allow the generation of two stereocenters in a single hydrogenation step.