Open AccessRaman Optical Activity: A Reliable Chiroptical Technique
Author(s) -
Jacques Haesler,
Werner Hug
Publication year - 2008
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2008.482
Subject(s) - raman optical activity , vibrational circular dichroism , raman spectroscopy , raman scattering , circular dichroism , absolute configuration , chemistry , instrumentation (computer programming) , analytical chemistry (journal) , optics , crystallography , physics , stereochemistry , computer science , organic chemistry , operating system
Vibrational optical activity (VOA) is a research field in full expansion. The two main areas where VOA is used are the determination of absolute configurations and the investigation of the secondary and tertiary solution structures of biopolymers. Commercial instrumentation is available since some time for vibrational circular dichroism (VCD) and, more recently, also Raman optical activity (ROA). Here, we describe a recent instrumental implementation of forward scattering, advances in the computational interpretation of ROA, and the determination of the mechanistically important absolute configuration of (4E)-3,3-dimethyl-5-[(2R,3R)-3-methyloxiran-2-yl]pent-4-en-2-one (1).