Peptides as Asymmetric Catalysts for Aldol Reactions | Zendy

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Peptides as Asymmetric Catalysts for Aldol Reactions

Author(s) -

Helma Wennemers

Publication year - 2007

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2007.276

Subject(s) - aldol reaction , catalysis , substrate (aquarium) , chemistry , combinatorial chemistry , organocatalysis , organic chemistry , enantioselective synthesis , biology , ecology

The article summarizes our research devoted to the development of peptidic catalysts for aldol reactions. Using the combinatorial method of 'catalyst–substrate coimmobilization' the peptides H-Pro-Pro-Asp-NH2 and H-Pro-D-Ala-D-Asp-NH2 were identified as highly active and selective catalysts for direct aldol reactions. The results demonstrate that the higher complexity of peptides in comparison to rigid small organocatalysts can be a good trade-off for higher activity.

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