Open AccessPeptides as Asymmetric Catalysts for Aldol Reactions
Author(s) -
Helma Wennemers
Publication year - 2007
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2007.276
Subject(s) - aldol reaction , catalysis , substrate (aquarium) , chemistry , combinatorial chemistry , organocatalysis , organic chemistry , enantioselective synthesis , biology , ecology
The article summarizes our research devoted to the development of peptidic catalysts for aldol reactions. Using the combinatorial method of 'catalyst–substrate coimmobilization' the peptides H-Pro-Pro-Asp-NH2 and H-Pro-D-Ala-D-Asp-NH2 were identified as highly active and selective catalysts for direct aldol reactions. The results demonstrate that the higher complexity of peptides in comparison to rigid small organocatalysts can be a good trade-off for higher activity.