Bimorpholines as Alternative Organocatalysts in Asymmetric Aldol Reactions | Zendy

Kadri Kriis | Zendy; Marju Laars | Zendy; Kristin Lippur | Zendy; Tõnis Kanger | Zendy

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Bimorpholines as Alternative Organocatalysts in Asymmetric Aldol Reactions

Author(s) -

Kadri Kriis,

Marju Laars,

Kristin Lippur,

Tõnis Kanger

Publication year - 2007

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2007.232

Subject(s) - aldol reaction , organocatalysis , chemistry , aldol condensation , intramolecular force , stereoselectivity , catalysis , selectivity , proline , combinatorial chemistry , acceptor , enantioselective synthesis , organic chemistry , amino acid , physics , biochemistry , condensed matter physics

Asymmetric organocatalytic aldol condensation is discussed on the basis of intramolecular and inter-molecular reactions. In addition to the widely used proline and its derivatives an application of the new type of the organocatalyst – bimorpholines in the above-mentioned reactions is described. The new catalyst has a unique C2-symmetric skeleton with four acceptor sites that makes it stereoselective and efficient. Small changes in the structure of the catalyst lead to a remarkable loss of selectivity.

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