Syntheses of Fluorescent Vitamin B12-Pt(II) Conjugates and their Pt(II) Release in a Spectroelectrochemical Assay | Zendy

P. Ruiz-Sánchez | Zendy; Stefan Mundwiler | Zendy; Roger Alberto | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Syntheses of Fluorescent Vitamin B12-Pt(II) Conjugates and their Pt(II) Release in a Spectroelectrochemical Assay

Author(s) -

P. Ruiz-Sánchez,

Stefan Mundwiler,

Roger Alberto

Publication year - 2007

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2007.190

Subject(s) - chemistry , fluorescence , imidazole , moiety , platinum , conjugate , adduct , cisplatin , stereochemistry , biochemistry , organic chemistry , biology , catalysis , mathematical analysis , physics , mathematics , quantum mechanics , chemotherapy , genetics

The cisplatin adduct of vitamin B12, cis-[PtCl(NH3)2B12]+ (1) reacts with dansyl-imidazole to form cis-[Pt(dansyl-imidazole)(NH3)2B12] (2). In a spectroelectrochemical assay, Co(III) in 2 was reduced to Co(II) under concomitant release of the Pt(II) complex. Since similar reduction occurs in the intracellular space, 2 can be used for studying cell uptake monitored by fluorescent microscopy. The insertion of a fluorescent marker into the platinum moiety will also facilitate the isolation of the platinum complex released from B12 and therefore to characterize its chemical authenticity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research