An Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate | Zendy

JohnRoss Rizzo | Zendy; Tony Y. Zhang | Zendy

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An Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

Author(s) -

JohnRoss Rizzo,

Tony Y. Zhang

Publication year - 2006

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.2006.580

Subject(s) - agonist , yield (engineering) , chemistry , peroxisome proliferator activated receptor , peroxisome , solvent , stereochemistry , combinatorial chemistry , receptor , organic chemistry , biochemistry , materials science , metallurgy

An asymmetric synthesis of navaglitazar, a peroxisome proliferator activated receptor (PPAR) ? agonist, from commercially available (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate, is described. The new synthesis features high overall yield, low solvent usage, crystalline intermediates and operational simplicity.

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