Open AccessAn Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate
Author(s) -
John Ross Rizzo,
Tony Y. Zhang
Publication year - 2006
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2006.580
Subject(s) - agonist , yield (engineering) , chemistry , peroxisome proliferator activated receptor , peroxisome , solvent , stereochemistry , combinatorial chemistry , receptor , organic chemistry , biochemistry , materials science , metallurgy
An asymmetric synthesis of navaglitazar, a peroxisome proliferator activated receptor (PPAR) ? agonist, from commercially available (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate, is described. The new synthesis features high overall yield, low solvent usage, crystalline intermediates and operational simplicity.