Open AccessAdvances in AIDS Chemotherapy: The Asymmetric Synthesis of CRIXIVAN®
Author(s) -
Paul J. Reider
Publication year - 1997
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1997.306
Subject(s) - stereocenter , human immunodeficiency virus (hiv) , computer science , combinatorial chemistry , nanotechnology , medicine , chemistry , enantioselective synthesis , virology , materials science , biochemistry , catalysis
The discovery and development of an efficient, practical asymmetric synthesis of the HIV Protease inhibitor CRIXIVAN® is described. Particular emphasis is placed on the selective installation of each of the five stereogenic centers as well as design strategies associated with the preparation of a complex pharmaceutical agent needed in multiton quantities.