Advances in AIDS Chemotherapy: The Asymmetric Synthesis of CRIXIVAN® | Zendy

Paul J. Reider | Zendy

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Advances in AIDS Chemotherapy: The Asymmetric Synthesis of CRIXIVAN®

Author(s) -

Paul J. Reider

Publication year - 1997

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.1997.306

Subject(s) - stereocenter , human immunodeficiency virus (hiv) , computer science , combinatorial chemistry , nanotechnology , medicine , chemistry , enantioselective synthesis , virology , materials science , biochemistry , catalysis

The discovery and development of an efficient, practical asymmetric synthesis of the HIV Protease inhibitor CRIXIVAN® is described. Particular emphasis is placed on the selective installation of each of the five stereogenic centers as well as design strategies associated with the preparation of a complex pharmaceutical agent needed in multiton quantities.

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