Asymmetric Hydrogenation vs. Resolution in the Synthesis of POSICOR®, a New Type of Calcium Antagonist | Zendy

Yvo Crameri | Zendy; Joseph Foricher | Zendy; Urs Hengartner | Zendy; Christian-Johannes Jenny | Zendy; Frank Kienzle | Zendy; Henri Ramuz | Zendy; Michelangelo Scalone | Zendy; Markus G. Schlageter | Zendy; Rudolf Schmid | Zendy; Shaoning Wang | Zendy

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Asymmetric Hydrogenation vs. Resolution in the Synthesis of POSICOR®, a New Type of Calcium Antagonist

Author(s) -

Yvo Crameri,

Joseph Foricher,

Urs Hengartner,

Christian-Johannes Jenny,

Frank Kienzle,

Henri Ramuz,

Michelangelo Scalone,

Markus G. Schlageter,

Rudolf Schmid,

Shaoning Wang

Publication year - 1997

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.1997.303

Subject(s) - mibefradil , asymmetric hydrogenation , chemistry , antagonist , catalysis , cascade , calcium , combinatorial chemistry , resolution (logic) , optically active , enantioselective synthesis , organic chemistry , chromatography , computer science , receptor , voltage dependent calcium channel , biochemistry , artificial intelligence

The pilot-plant-scale synthesis of (S)-2-(4-fluorophenyl)-3-methylbutanoic acid by asymmetric hydrogenation of 2-(4-fluorophenyl)-3-methylbut-2-enoic acid with the [Ru((R)-MeOBIPHEP)(OAc)2]-catalyst is described. The hydrogenation was performed in a continuous mode in a cascade stirred-tank reactor system at 270 bar pressure. The (S)-2-(4-fluorophenyl)-3-methylbutanoic acid is an important optically active intermediate in the synthesis of mibefradil, a new type of calcium antagonist.

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