Catalytic Asymmetric Hydrogenation in the Manufacture of d-Biotin and Dextromethorphan | Zendy

René Imwinkelried | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Catalytic Asymmetric Hydrogenation in the Manufacture of d-Biotin and Dextromethorphan

Author(s) -

René Imwinkelried

Publication year - 1997

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.1997.300

Subject(s) - dextromethorphan , phosphine , asymmetric hydrogenation , catalysis , catalytic hydrogenation , chemistry , biotin , combinatorial chemistry , noyori asymmetric hydrogenation , organic chemistry , enantioselective synthesis , biochemistry , medicine , anesthesia

Two enantiomerically pure products, (+)-biotin and dextromethorphan, have been chosen to illustrate the acquisition, development, and implementation of the catalytic asymmetric hydrogenation technology at Lonza Fine Chemicals. Taking advantage of the recently developed Ciba-Geigy ferrocenyl-type phosphine ligands, processes for the stereoselective hydrogenation of a C=C- and a C=N bond, respectively, have been developed and successfully scaled up.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research