Open AccessCatalytic Asymmetric Hydrogenation in the Manufacture of d-Biotin and Dextromethorphan
Author(s) -
René Imwinkelried
Publication year - 1997
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1997.300
Subject(s) - dextromethorphan , phosphine , asymmetric hydrogenation , catalysis , catalytic hydrogenation , chemistry , biotin , combinatorial chemistry , noyori asymmetric hydrogenation , organic chemistry , enantioselective synthesis , biochemistry , medicine , anesthesia
Two enantiomerically pure products, (+)-biotin and dextromethorphan, have been chosen to illustrate the acquisition, development, and implementation of the catalytic asymmetric hydrogenation technology at Lonza Fine Chemicals. Taking advantage of the recently developed Ciba-Geigy ferrocenyl-type phosphine ligands, processes for the stereoselective hydrogenation of a C=C- and a C=N bond, respectively, have been developed and successfully scaled up.