Open AccessCatalytic Enantioselective Reactions from Research to Application. Diarylmethanol-Containing Auxiliaries as a Study Case
Author(s) -
Dieter Seebàch,
Albert K. Beck
Publication year - 1997
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1997.293
Subject(s) - enantioselective synthesis , moiety , catalysis , stoichiometry , aryl , chemistry , organic chemistry , metal , combinatorial chemistry , alkyl
Chiral auxiliaries – in the broadest possible definition of the term – can be obtained by Grignard reactions of Aryl-MgX with chiral esters R*CO2R. The products formed all contain a diarylmethanol structural moiety. They can be used in stoichiometric and catalytic enantioselective reactions, preferably as ligands on metal centers. They have also found applications for enantioselective inclusions, for solid-phase reactions, and for liquid-crystal preparations.