Open AccessBiopharmaceuticals from Mammalian Cells
Author(s) -
John Birch,
Susan Bright
Publication year - 1997
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1997.290
Subject(s) - monoclonal antibody , protein expression , computational biology , isolation (microbiology) , gene , biology , antibody , biochemistry , genetics , bioinformatics
The advent of genetic engineering and monoclonal antibody technologies has made possible the manufacture of a wide range of pharmaceutical proteins. Many of these proteins are made in mammalian cell culture. This has required the development of novel gene-expression systems as well as technology for the large-scale culture of cells and for the isolation of proteins to exacting standards of purity. Lonza has established facilities in the UK and the USA for the contract development and manufacture of these proteins.