Open AccessLipase-Catalyzed Dynamic Kinetic Resolution of Chiral Amines: Use of Palladium as the Racemization Catalyst
Author(s) -
Manfred T. Reetz,
Klaus Schimossek
Publication year - 1996
Publication title -
chimia international journal for chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1996.668
Subject(s) - racemization , kinetic resolution , catalysis , palladium , candida antarctica , lipase , chemistry , biocatalysis , organic chemistry , transition metal , enantioselective synthesis , enzyme , reaction mechanism
The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75–77% (ee = 99%).
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