Consideration of Solid-Phase Synthesis with Reference to Quinolone Antibiotics | Zendy

Alasdair A. MacDonald | Zendy; Sheila H. DeWitt | Zendy; Robert Ramageu | Zendy

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Consideration of Solid-Phase Synthesis with Reference to Quinolone Antibiotics

Author(s) -

Alasdair A. MacDonald,

Sheila H. DeWitt,

Robert Ramageu

Publication year - 1996

Publication title -

chimia international journal for chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 55

eISSN - 2673-2424

pISSN - 0009-4293

DOI - 10.2533/chimia.1996.266

Subject(s) - quinolone , solid phase synthesis , phase (matter) , impurity , combinatorial chemistry , chemistry , antibiotics , biochemical engineering , organic chemistry , engineering , biochemistry , peptide

The general utility of solid-phase synthesis for creating libraries of compounds will be discussed with particular reference paid to the development of a solid-phase organic synthetic route to quinolones. Using the DIVERSOMER® technology a library of quinolones have been prepared, purified and analyzed. Additionally, the issue of resin impurities and by-products will be discussed.

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