Open AccessConsideration of Solid-Phase Synthesis with Reference to Quinolone Antibiotics
Author(s) -
Alasdair A. MacDonald,
Sheila DeWitt,
R. Ramage
Publication year - 1996
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1996.266
Subject(s) - quinolone , solid phase synthesis , phase (matter) , impurity , combinatorial chemistry , chemistry , antibiotics , biochemical engineering , organic chemistry , engineering , biochemistry , peptide
The general utility of solid-phase synthesis for creating libraries of compounds will be discussed with particular reference paid to the development of a solid-phase organic synthetic route to quinolones. Using the DIVERSOMER® technology a library of quinolones have been prepared, purified and analyzed. Additionally, the issue of resin impurities and by-products will be discussed.