Open Access(Trimethylsilyl)alanine: a Metabolically Stable 'Bio-Isostere' for Phenylalanine
Author(s) -
Beat Weidmann
Publication year - 1992
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1992.312
Subject(s) - isostere , phenylalanine , trimethylsilyl , alanine , chemistry , stereochemistry , amino acid , organic chemistry , biochemistry
The preparation of protected derivatives of enantiomerically pure β-(trimethylsilyl)alanine (1) and their chemical properties are decribed. Examples of renin inhibitory peptides, containing 1 are given, which demonstrates its use as a 'bio-isosteric' replacement for phenylalanine (2).